Peripheral Blood Invariant Natural Killer T Cells of Pig-Tailed Macaques
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چکیده
منابع مشابه
Peripheral Blood Invariant Natural Killer T Cells of Pig-Tailed Macaques
In humans, invariant natural killer T (iNKT) cells represent a small but significant population of peripheral blood mononuclear cells (PBMCs) with a high degree of variability. In this study, pursuant to our goal of identifying an appropriate non-human primate model suitable for pre-clinical glycolipid testing, we evaluated the percentage and function of iNKT cells in the peripheral blood of pi...
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Background: Invariant natural killer cells (iNKT) are an important immunoregulatory T cell subset. Currently several flow cytometry-based approaches exist for the identifi-cation of iNKT cells, which rely on using the 6B11 monoclonal antibody or a combina-tion of anti-Vα24 and anti-Vβ11 antibodies. Objective: The aim of this study was to compare the ability of two flow cytometry-based methods f...
متن کاملInvariant Natural Killer T Cells
Invariant Natural killer T cell (iNKT cells) are a subset of T cells, which are narrowly defined as a T cell lineage expressing a semi-invariant CD1d-restricted T cell Receptors (TCRs) composed by Vα24-Jα18/Vβ11 in human, and Vα14-Jα18/Vβ8,Vβ7, and Vβ2 in mouse. Unlike conventional T cells which recognize peptides bound to highly polymorphic major histocompatibility complex (MHC) class I and II...
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interleukin-12 (il-12) is a key cytokine involved in regulating the balance between th1 and th2 cells by promoting th1 response. a reduced capacity to produce this cytokine could lead to aberrant th2 development. on the same aspect significant impact of il-12 on invariant natural killer t (inkt) cells was reported. therefore, we examined the serum levels of il-12 and the absolute number of peri...
متن کاملIncreased Th2-like Invariant Natural Killer T cells in Peripheral Blood From Patients With Asthma
PURPOSE Invariant natural killer T (iNKT) cells might play an important role in asthma pathogenesis in humans. Our previous study found no difference in the number of blood iNKT cells between asthma patients and controls. However, few studies have examined the function of blood iNKT cells in human asthma. METHODS Twenty asthma patients and eight controls were included in this study. Blood iNK...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2012
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0048166